Guidelines & research updates
International clinical guidelines and summaries of recent studies, updated as new evidence is published.
Joint Clinical Practice Guideline on Benzodiazepine Tapering: Considerations When Risks Outweigh Benefits (opens in a new tab)
GuidelineEvidence-based clinical recommendations for safely tapering benzodiazepines when treatment risks outweigh benefits. Covers individualized dose reduction, withdrawal management, prevention of complications, shared decision-making, and monitoring to minimize withdrawal symptoms and support successful discontinuation.
The ASAM Clinical Practice Guideline on Alcohol Withdrawal Management (opens in a new tab)
GuidelineEvidence-based clinical recommendations from the American Society of Addiction Medicine (ASAM) for assessing and managing alcohol withdrawal. Covers risk stratification, withdrawal severity, pharmacological treatment, monitoring, prevention of seizures and delirium, and management in inpatient and outpatient settings.
The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia, Third Edition (opens in a new tab)
GuidelineThe American Psychiatric Association's evidence-based clinical guideline provides recommendations for the assessment and treatment of schizophrenia, including antipsychotic pharmacotherapy, long-acting injectable medications, management of treatment-resistant schizophrenia, and psychosocial interventions.
Efficacy of Different Combination Therapies for Mania in Bipolar Disorder: A Systematic Review and Meta-Analysis (opens in a new tab)
ResearchA meta-analysis of 10 randomized trials involving 842 patients compared ziprasidone and olanzapine combined with mood stabilizers in bipolar mania. Overall efficacy was comparable, but ziprasidone showed greater improvement in manic symptoms, fewer adverse reactions, and higher BDNF levels.
The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder (opens in a new tab)
GuidelineEvidence-based clinical recommendations for managing stimulant use disorders, including cocaine and amphetamine use. Covers intoxication, withdrawal, behavioral therapies, and pharmacological options, including off-label use of bupropion, naltrexone, and modafinil.
Treatment of central disorders of hypersomnolence: an American Academy of Sleep Medicine clinical practice guideline (opens in a new tab)
GuidelineIntroduction: This guideline establishes clinical practice recommendations for the treatment of central disorders of hypersomnolence in adults and children
The American Society of Addiction Medicine Handbook of Addiction Medicine, Third Edition (opens in a new tab)
GuidelineA comprehensive clinical handbook covering the diagnosis, treatment, and management of substance use disorders. It addresses alcohol, opioid, stimulant, and other addictions, including withdrawal management, pharmacotherapy, behavioral interventions, harm reduction, and long-term recovery.
For healthcare professionals. The materials are informational and do not replace clinical judgment.
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